Healthy people with genetic risks in PPMI?

Hi, just as a quick update on this topic. I was looking to the new curated dataset from a few weeks ago (2025-11-12). I can see there was an update for the “subgroup”, and now the “Original Variables” do not include the `CON…` anymore, it was added that the original dataset used now includes the “iu_genetic_consensus”, and in the Derivation Notes we now have a clarification saying “Genetic consensus variant data from the “iu_genetic_consensus” file are used when available. If genetic consensus data is missing, use enrollment (ENRL) indicator.”

After checking the “iu_genetic_consensus” CSV now I can see how the genetic subgroups for these healthy people came from, so at least this part is clearer now (I could swear I didn’t see this file in LONI before, but the version date is for around a week before I created this topic, so I guess I just missed it).

However, I believe some things are still not clear: how is it possible that this “genetic consensus” data is different from the “Participant_Status” CSV? And, in this case, shouldn’t this still mean that if these people have these genetic risks at baseline, they should have gone into the Prodromal cohort instead? :thinking: I feel I’m missing some key methodological information.