Hello Everyone -- Fox Insight microbiome subsidy (orthostatic hypotension)

Analyzing and Reusing Data
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Hello Everyone,

In the Fox Insight microbiome sub study, I am interested in identifying individuals with orthostatic hypotension. I am wondering if the variables ‘ImpactThinkDizzy’ (Feeling lightheaded or dizzy) and ‘NonMoveDizzy’ (Have you experienced feeling light-headed, dizzy or weak standing from sitting or lying in the last month?) and the best descriptors?

Thank you so much and all the best,

Minna Schmidt

Postdoc

Andersen lab, The Buck Institute

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Hi Minna,

I’d recommend “NonMoveDizzy”. If you are interested in orthostatic hypotension, NonMoveDizzy specifically isolates symptoms that result from standing (relative to supine/sitting positions) whereas ImpactThinkDizzy seems more general (can occur in all positions). I used NonMoveDizzy in this study for reference.

Another reason why you might consider NonMoveDizzy for microbiome related work is the timing of that survey relative to microbiome data collection. ImpactThinkDizzy is from a more recent survey, whereas NonMoveDizzy might nicely align with the timing of sample collection. Here is a somewhat outdated timeline for reference.

Best,

Matt

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Thank you so much Matt for this great information! I see that the ‘NonMove’ survey has a greater completion profile in my cohort than ImpactThink! Thank you very much for the reference! However, I am having some issues opening it. Would you be able to provide the name of the article or possible a different link?

All the very best,

Minna.

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Hi Minna,

Apologies for the bad link. Here is a better one: https://doi.org/10.5281/zenodo.10914682

I’ve also updated my original post with the correct link.

Thanks!

Matt

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Thank you so much Matt! Amazing! I really appreciate it!!

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Hi again Matt,

I am also wondering if you have any suggestions for determining motor symptom asymmetry/symmetry? I thought about ‘SidePDOnset’ but I am not sure. I see that the FIVE study assessed motor symmetry, but unfortunately, it doesn’t overlap well with the cohort I have chosen to work with (only 4 individuals.) Do you have any recommendations?

Thank you once again or the paper you sent and wrote! It has been extremely helpful!

All the very best,

Minna.

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Just for the discussion for your paper, I’d recommend mentioning that a lot of patients with orthostatic hypotension are asymptomatic. So relying only on self-report symptoms is a shortcoming for orthostatic hypotension. Nothing you can do for Fox Insight and you should use whatever’s available of course, but just mentioning so you can consider this point in your discussion!

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Oh thank you so much Ece! That is a great point and I will make sure to include in my discussion!

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Hi Minna,

It does seem that SidePDOnset does get at motor asymmetry somewhat tangentially and perhaps at a different point in the disease course than you intend. It may depend on the research question, but I wonder if you can use SidePDOnset and the “Handedness Questionnaire (Edinburgh Handedness short form)” to roughly estimate a weighted asymmetry score. Just an idea!

Best,

Matt