When the Journal Club got creative (literally)

I didn’t know what to present at my lab’s Journal Club… and I’m making it everyone’s problem.

Like in many labs, each member has to present one paper per semester. But in ours, that’s complicated: we’re a mix of clinical recruiters, wet-lab people, dry-lab analysts, genetics, immunology, Parkinson’s research… Finding a paper that’s useful, interesting, and doesn’t make half of the lab run away is a challenge.

When it was my turn, I refused to present yet another methods paper with 200 UMAPs. I wanted something that would make us think and connect as a team. And I think I found it.

The Paper

The study I presented investigated whether creative experiences — like dancing, playing music, drawing, or gaming — can protect the brain from aging. They used EEG/MEG-based “brain clock” models and applied machine learning, graph theory, and biological modeling in a diverse sample.

They compared brain age gaps (BAGs) between people with different levels of creative experience — including experts vs. non-experts — and also before and after a short creative gaming training.

What Did They Find?

Creative experiences slow down brain aging.

  • The effects were strongest in frontoparietal regions, key for attention, coordination, and imagination.

  • Neural plasticity and network efficiency explained these benefits.

  • The effects were broad — seen across dance, music, visual arts, and gaming.

  • Short-term learning can improve brain health.

  • BAGs are emerging as a robust marker of brain health.

Why Did It Work in My Lab?

Because everyone — from those in clinical work to those doing network analysis — found something that resonated. Some thought about their patients, others about their own hobbies, and others about how to design more human-centered interventions.

Share!

@DCoP_Innovators and community,

Do you have a paper that made you go, “Wow, more people need to see this”?
I’d love to make a list of papers that deserve to be shared in Journal Clubs or just among curious colleagues.

8 Likes

i love this paper:

i love that it starts with a Shakespeare quote, gives descriptions, history, and perspective on why things were called what they are. it’s a viewpoint, but i think it really opens the doors to the discussion on how to define diseases and why we define them that way. it triggers conversations bringing in info from other diseases too, so you don’t necessarily have to have extensive movement/dementia training. Weintraub is also a lovely human, so i’m biased in that sense too but i really enjoy his writing :blush:

Movement Disorders - 2023 - Weintraub - What s in a Name The Time Has Come to Unify Parkinson s Disease and Dementia with.pdf (129.2 KB)

5 Likes

When I had to present a paper for our Journal Club at Cleveland Clinic, I was finishing my paper and was only reading and writing about Parkinson’s disease, genetic diversity, and GWAS. Since the audience wasn’t made up only of geneticists, I thought it’d be nice to pick something a little different. So I asked a friend for a suggestion (one of the biggest brain that I know), and he sent me a paper with a great title. I liked it so much that I sent it straight to the Journal Club organizer without reading it:

I won’t lie: the paper was awesome. The authors did an incredible job explaining why we shouldn’t ignore the genetic component of certain traits (especially considering how badly that went in the past ), did a huge literature review on “nature versus nurture”, and ran some really impressive analyses with PRS, comparison with different phenotypes, and population-level GWAS, etc

But I had a problem: It was a bad paper for a Journal Club. It was the kind of paper you need to read slowly, stop to think about, maybe learn new concepts, and take time to digest the figures. When the day came, the presentation went fine, specially but the audience ended up being mostly my lab (they don’t expect too much from me) and two other people. The room was empty because my talk happened to be at the exact same time as a “big brain” guest giving a talk about “big brain stuff.”

5 Likes

Hi Paula,

You made me remember this paper, that was recently published as a pre-print, from the NIH group I worked with: https://www.biorxiv.org/content/10.1101/2025.09.30.679553v1

LRS in aging prediction.pdf (828.2 KB)

Thanks for sharing!

2 Likes

I also love a good dramatic start! Thank you for sharing, looks super interesting!

1 Like