Hello everyone! I’m using the CSF SomaLogic proteomic dataset under project 151. I was doing some sanity checks and discovered that the values of MAPT and SNCA (both) do not correlate strongly with the corresponding values at baseline for (p)tau, and alpha-synuclein (async), available in the curate…

Hi Paula, thanks for sending that link which indeed I’ve checked before too. Unfortunately as far as I can tell it “just” has the information I already knew about this dataset, and not the specific information about the aptamers. Tiago.

I also have this question! Hoping that someone with direct knowledge of the PPMI Project 151 will see the thread here (does anyone know who to tag??) I tried looking up the SomaLogic website for technical details, but didn’t get very far. Project 151 is a 4k panel, but SomaLogic no longer offers th…

@gginnan @jgottesman do you happen to know the right person to tag maybe?

That’s a great question, @tiago.azevedo ! Wonder if @jodiefm or @dalonso would have any insight to offer?

@vcatterson I can confirm that all the Project 151 files are as provided by the PI’s lab, PPMI almost never further curates/amends individual project data returns. The Curated Data Cut, Working Group, and derived project data returns are the only places you should expect further curation beyond what…

Thanks everybody for all the tags and ideas. For completeness, just to leave here that I contacted project 151’s PI by email and indeed I got confirmation that they also don’t know the answer to this question and only SomaLogic could provide the answer. Unfortunately, SomaLogic hasn’t answered my di…

Thanks for this further information about curation, @lkirsch ! Very helpful to know more. In light of @tiago.azevedo 's response from the 151 PI, I think we all need to pester SomaLogic until they will provide us the answer :wink:

Hi. We are also analysing this dataset. I’m not sure about the 4K but in the lager panels (11K) there are multiple aptamers to a-syn that do not correlate with each other or show the same directions of change in our cohort. I’m not sure that is unusual. A lot of different ELISA platforms using antib…

Thanks for your perspective on this, @nicdzam ! You’re right: there are multiple aptamers tagging certain proteins of interest, even in the 4K, and the count numbers do not exactly correlate with each other. As I understand it, this is to be expected because the aptamers are tagging different section…

Asking for help understanding SomeLogic proteomics data

Analyzing and Reusing Data

psaffie November 24, 2025, 5:30pm 2

Hi @tiago.azevedo !! I have never done that, but I found this post from @mcbrumm that maybe could be of some help Newly Released PPMI Proteomics Curated Datasets

Hope it gives you some light!

Paula

Topic		Replies	Views
Best way to match SOMAScan sequence IDs to gene IDs? Accessing and Understanding Data	14	171	September 23, 2026
Process for updating the mapping of PPMI SomaScan sequence IDs to human genes Accessing and Understanding Data how-to , proteomics , ppmi	5	85	October 16, 2026
PPMI Longitudinal CSF SomaLogic Proteomic Data Accessing and Understanding Data proteomics , ppmi , csf	4	119	December 7, 2025
Is α-synuclein seed amplification analysis data already present in the PPMI data? Analyzing and Reusing Data ppmi , data-access , alpha-synuclein	6	281	August 18, 2023
Newly Released PPMI Proteomics Curated Datasets Data Sharing and Publications data-sharing , proteomics , ppmi	6	499	December 9, 2025

Asking for help understanding SomeLogic proteomics data

Related topics