The Parkinson’s Progression Markers Initiative (PPMI) recently released a new curated proteomics data cut. It’s important to note that the new curated proteomics data cut can be merged with other PPMI variables using the PATNO and EVENT_ID variables. This data cut encompasses six datasets from four distinct proteomics platforms, outlined below:
| PPMI Project ID(s) | Platform/Method | Matrix | Samples | Analytes |
|---|---|---|---|---|
| 151 | SomaLogic 4K | CSF | 1,153 | 4,785 |
| 177 | DIA-MS | CSF | 2,283 | 291 |
| 177 | DIA-MS | Plasma | 949 | 186 |
| 190 | OmicEra (MS) | Urine | 1,162 | 6,487 |
| 196; 222; 9000 | Olink Explore 1536 | CSF | 799 | 1,463 |
| 196; 222; 9000 | Olink Explore 1536 | Plasma | 1,031 | 1,463 |
LONI hosts both the raw data and the curated data files. Here are some details on how to access the curated files:
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If this is your first time accessing PPMI data, I recommend referring to the following thread for additional background information, including instructions on how to gain access: An Introduction to the PPMI Dataset.
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Go to the LONI login page and navigate to the Biospecimen: Proteomic Analysis section. The data cut is labeled as “PPMI Proteomic Working Group Curated Datasets” (Version: 2024-05-29) and downloads as a single zip file containing 6 Excel files, 1 CSV file, and 1 PDF.
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Additionally, the PPMI Data User Guide serves as an introduction and reference for understanding PPMI data. It provides instructions on interpreting PPMI data, including guidance on accessing curated data cuts (Section 11) and individual project proteomics data (Section 8).
Curious if anyone has plans or interest in utilizing the data from this new release? Please feel free to send me a message or reply here!